Premium
Long‐Term Efficacy of Oxybutynin for Palmar and Plantar Hyperhidrosis in Children Younger than 14 Years
Author(s) -
Wolosker Nelson,
Teivelis Marcelo P.,
Krutman Mariana,
Paula Rafael P.,
Schvartsman Claudio,
Kauffman Paulo,
Campos José R. M.,
PuechLeão Pedro
Publication year - 2014
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12385
Subject(s) - oxybutynin , hyperhidrosis , medicine , quality of life (healthcare) , palmar hyperhidrosis , retrospective cohort study , cohort , surgery , anesthesia , overactive bladder , alternative medicine , nursing , pathology
Oxybutynin for treating hyperhidrosis in children has been evaluated only in short‐term studies. We aimed to investigate the long‐term effects of oxybutynin in treating children with palmar and plantar hyperhidrosis who had not undergone surgery and who were monitored for at least 6 months (median 19.6 mos). A cohort of 97 patients was evaluated retrospectively, with particular attention to 59 children (ages 4–14 yrs) who were treated for longer than 6 months. Their quality of life ( QOL ) was evaluated using a validated clinical questionnaire before and after 6 weeks of pharmacologic therapy. A self‐assessment of hyperhidrosis was performed after 6 weeks and after the last consultation. By their final office visit, more than 91% of the children with hyperhidrosis treated with oxybutynin experienced moderate or great improvement in their level of sweating and 94.9% experienced improvement in QOL . More than 90% of children reported improvement of hyperhidrosis at other sites. Dry mouth was the most common side effect. Oxybutynin appears to be an effective treatment option for children with hyperhidrosis, and positive results are maintained over the long term (median 19.6 mos).