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Bullous Dermolysis of the Newborn: Four New Cases and Clinical Review
Author(s) -
RadkevichBrown Olga,
Shwayder Tor
Publication year - 2013
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12230
Subject(s) - medicine , anchoring fibrils , epidermolysis bullosa , immunofluorescence , dermatology , pathology , collagen fibril , anatomy , ultrastructure , antibody , immunology
Bullous dermolysis of the newborn ( BDN ) is a subtype of dystrophic epidermolysis bullosa caused by mutations in type VII collagen resulting in disorganized anchoring fibrils and sublamina densa blister formation. Disease activity is usually confined to the first year of life, with restoration of physiologic type VII collagen localization. We report four new cases of BDN and review the utility of immunofluorescence mapping in establishing the diagnosis.