Diagnostic Value of Polymerase Chain Reaction Analysis of Skin Biopsies in Purpura Fulminans | Zendy

Beau Caroline | Zendy; Vlassova Natalia | Zendy; Sarlangue Jean | Zendy; Brissaud Olivier | Zendy; LéautéLabrèze Christine | Zendy; Boralevi Franck | Zendy

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Diagnostic Value of Polymerase Chain Reaction Analysis of Skin Biopsies in Purpura Fulminans

Author(s) -

Beau Caroline,

Vlassova Natalia,

Sarlangue Jean,

Brissaud Olivier,

LéautéLabrèze Christine,

Boralevi Franck

Publication year - 2013

Publication title -

pediatric dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 73

eISSN - 1525-1470

pISSN - 0736-8046

DOI - 10.1111/pde.12181

Subject(s) - purpura fulminans , medicine , polymerase chain reaction , skin biopsy , antibiotics , biopsy , microbiological culture , pathology , dermatology , microbiology and biotechnology , gene , bacteria , biology , biochemistry , genetics

Even though prompt diagnosis and treatment of purpura fulminans ( PF ) is essential to reduce mortality, early administration of antibiotics may preclude identification of the causative agent by standard bacterial cultures and thus render definitive diagnosis impossible. Here we present a case of an infant with PF and negative bacterial cultures for whom polymerase chain reaction ( PCR ) analysis of a cutaneous biopsy specimen obtained 4 days after initiation of antibiotics identified the genomic sequence of N eisseria meningitidis genogroup C . When bacterial cultures fail to provide useful information, PCR of skin biopsy specimens can be a valuable diagnostic tool in PF .

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