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Toxic Epidermal Necrolysis in a Child Successfully Treated with Infliximab
Author(s) -
ScottLang Victoria,
Tidman Michael,
McKay David
Publication year - 2012
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.12029
Subject(s) - medicine , toxic epidermal necrolysis , infliximab , carbamazepine , dermatology , tumor necrosis factor alpha , surgery , psychiatry , epilepsy
Abstract A 7‐year‐old boy developed severe toxic epidermal necrolysis ( TEN ) secondary to carbamazepine and was transferred to our center after further deterioration despite receiving one dose of intravenous immunoglobulin. After administration of one dose of infliximab, there was a clear halting of progression of blistering and an apparent dramatic improvement. We consider it likely that the administration of infliximab led to the improvement in this child and that anti‐tumor necrosis factor‐alpha therapy may be a logical treatment for TEN , given the possible underlying pathologic process. Well‐conducted studies on the safety and efficacy of any such treatment are urgently required.