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Unsuccessful reduction of high‐frequency alpha activity during cognitive activation in schizophrenia
Author(s) -
Jang KukIn,
Oh Jihoon,
Jung Wookyoung,
Lee Sangmin,
Kim Sungkean,
Huh Seung,
Lee SeungHwan,
Chae JeongHo
Publication year - 2019
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12818
Subject(s) - resting state fmri , alpha (finance) , electroencephalography , cognition , schizophrenia (object oriented programming) , audiology , psychology , brain activity and meditation , elementary cognitive task , neuroscience , medicine , developmental psychology , psychiatry , psychometrics , construct validity
Aims Electroencephalogram (EEG) alpha activity during resting state reflects the ‘readiness’ of an individual to respond to the environment; this includes the performance of cognitive processes. Alpha activity is reported to be attenuated in schizophrenia (SCZ). Understanding the interaction between alpha activity during rest and when cognitively engaged may provide insights into the neural circuitry, which is dysfunctional in SCZ. This study investigated the changes of alpha activity between resting state and cognitive engagement in SCZ patients. Methods Thirty‐four SCZ patients and 29 healthy controls (HC) were recruited. EEG was performed in the resting state and during an auditory P300 task. All experimental procedures followed the relevant institutional guidelines and regulations. Results In SCZ, high‐frequency alpha activity was reduced in the resting state. High‐frequency alpha source density was decreased in both the resting‐state and a P300 task condition in patients, compared to HC. HC, but not SCZ patients, showed a reduction in high‐frequency alpha source density during the P300 task compared to the resting state. The negative correlation between high‐frequency alpha source density in the resting state and positive symptoms was significant. Conclusions High‐frequency alpha activity in SCZ patients and its unsuccessful reduction during cognitive processing may be biological markers of SCZ.