Premium
Comparison of changes in the oxygenated hemoglobin level during a ‘modified rock‐paper‐scissors task’ between healthy subjects and patients with schizophrenia
Author(s) -
Sato Mamoru,
Shoji Yoshihisa,
Morita Kiichiro,
Kato Yusuke,
Ishii Youhei,
Nakano Shinya,
Uchimura Naohisa
Publication year - 2018
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12653
Subject(s) - positive and negative syndrome scale , psychology , schizophrenia (object oriented programming) , correlation , audiology , cognition , region of interest , task (project management) , gaze , neuroscience , psychosis , psychiatry , medicine , geometry , mathematics , management , psychoanalysis , economics , radiology
Aim The purpose of this study, using single‐event‐related near‐infrared spectroscopy (NIRS), was to examine the psychophysiological and social function assessment of 30 schizophrenic patients during a modified rock‐paper‐scissors task. Methods We set up a screen in front of the subjects, on which pictures of hand‐gestures for rock, paper, and scissors were randomly presented. Subjects were asked to give verbal answers under the conditions of win, lose, and draw, respectively. Using the 44‐channel NIRS system, we evaluated the maximum amplitude of oxygenated hemoglobin, latency, and the area based on the arithmetic mean of resulting values after the task between 30 outpatients with schizophrenia and 30 healthy subjects, and analyzed the frontal pole area, dorsolateral prefrontal region, and parietal association area as regions of interest (ROI). Results In schizophrenic patients, oxygenated hemoglobin changes (Δoxy‐Hb) when losing the task showed a significantly lower level of Δoxy‐Hb in ROI than controls. In addition, a significant positive correlation was observed between the Global Assessment of Functioning Scale and Δoxy‐Hb in ROI, and a significant negative correlation was observed between the Negative Syndrome scale of the Positive and Negative Syndrome Scale and Δoxy‐Hb in ROI. Conclusion From these results, we conclude that Δoxy‐Hb levels when performing the modified rock‐paper‐scissors task assessed using NIRS may be a useful psychophysiological marker to evaluate the cognitive and social functions of schizophrenic patients.