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Therapeutic role of rifampicin in Alzheimer's disease
Author(s) -
Yulug Burak,
Hanoglu Lütfü,
Ozansoy Mehmet,
Isık Dogan,
Kilic Ulkan,
Kilic Ertugrul,
Schabitz Wolf Rüdiger
Publication year - 2018
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12637
Subject(s) - neuroprotection , rifampicin , neuroscience , disease , medicine , cognition , neuroimaging , neurology , alzheimer's disease , psychology , pharmacology , pathology , tuberculosis
Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro‐cognitive effects of rifampicin that are mediated by its anti‐inflammatory, anti‐tau, anti‐amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro‐cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.