Premium
Association between the scores of the Japanese version of the Brief Assessment of Cognition in Schizophrenia and whole‐brain structure in patients with chronic schizophrenia: A voxel‐based morphometry and diffusion tensor imaging study
Author(s) -
Hidese Shinsuke,
Ota Miho,
Matsuo Junko,
Ishida Ikki,
Hiraishi Moeko,
Teraishi Toshiya,
Hattori Kotaro,
Kunugi Hiroshi
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12560
Subject(s) - fractional anisotropy , white matter , diffusion mri , corpus callosum , psychology , schizophrenia (object oriented programming) , internal capsule , magnetic resonance imaging , superior longitudinal fasciculus , grey matter , voxel based morphometry , cognition , audiology , neuroscience , psychiatry , medicine , radiology
Aim The Brief Assessment of Cognition in Schizophrenia (BACS) is a concise tool designed to evaluate cognitive deficits in schizophrenia. We examined the possible association between BACS scores and whole‐brain structure, as observed using magnetic resonance imaging with a relatively large sample. Methods The study sample comprised 116 patients with schizophrenia (mean age, 39.3 ± 11.1 years; 66 men) and 118 healthy controls (HC; mean age, 40.0 ± 13.6 years; 58 men) who completed the Japanese version of the BACS (BACS‐J). All participants were of Japanese ethnicity. The magnetic resonance imaging volume and diffusion tensor imaging data were processed with voxel‐based morphometry and tract‐based spatial statistics, respectively. Results There were significant reductions in the regional gray matter volumes and white matter fractional anisotropy values in patients with schizophrenia compared to HC. For the gray matter areas, the working memory score had a significant positive correlation with the anterior cingulate and medial frontal cortices volumes in the patients. For the white matter areas, the motor speed score had a significant positive correlation with fractional anisotropy values in the corpus callosum, internal capsule, superior corona radiata, and superior longitudinal fasciculus in the patients. However, there was no significant correlation among either the gray or white matter areas in the HC. Conclusion Our results suggest that among the BACS‐J measures, the working memory and motor speed scores are associated with several structural alterations in the brains of patients with schizophrenia.