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Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia
Author(s) -
Liu YaoNan,
Lu SiYao,
Yao Jun
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12528
Subject(s) - induced pluripotent stem cell , neuroscience , schizophrenia (object oriented programming) , bipolar disorder , neural stem cell , psychology , psychiatry , biology , stem cell , embryonic stem cell , cognition , genetics , gene
The etiology of neuropsychiatric disorders, such as schizophrenia and bipolar disorder, usually involves complex combinations of genetic defects/variations and environmental impacts, which hindered, for a long time, research efforts based on animal models and patients’ non‐neuronal cells or post‐mortem tissues. However, the development of human induced pluripotent stem cell (iPSC) technology by the Yamanaka group was immediately applied to establish cell research models for neuronal disorders. Since then, techniques to achieve highly efficient differentiation of different types of neural cells following iPSC modeling have made much progress. The fast‐growing iPSC and neural differentiation techniques have brought valuable insights into the pathology and neurobiology of neuropsychiatric disorders. In this article, we first review the application of iPSC technology in modeling neuronal disorders and discuss the progress in the accompanying neural differentiation. Then, we summarize the progress in iPSC‐based research that has been accomplished so far regarding schizophrenia and bipolar disorder.