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Longitudinal study examining abnormal white matter integrity using a tract‐specific analysis in individuals with a high risk for psychosis
Author(s) -
Saito Junichi,
Hori Masaaki,
Nemoto Takahiro,
Katagiri Naoyuki,
Shimoji Keigo,
Ito Shinya,
Tsujino Naohisa,
Yamaguchi Taiju,
Shiraga Nobuyuki,
Aoki Shigeki,
Mizuno Masafumi
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12515
Subject(s) - splenium , white matter , fractional anisotropy , corpus callosum , psychosis , diffusion mri , psychology , magnetic resonance imaging , lateral ventricles , medicine , psychiatry , neuroscience , radiology
Aim Although volume reductions in the grey matter have been previously observed in individuals with an at‐risk mental state ( ARMS ) for psychosis, the features of white matter integrity and their correlation with psychiatric symptoms remain unclear. Methods Forty‐six ARMS subjects were examined using magnetic resonance imaging ( MRI ) to acquire diffusion tensor imaging ( DTI ); the subjects were also evaluated using the S cale of P rodromal S ymptoms at baseline and at 52 weeks. Sixteen healthy controls also underwent MRI scanning. The DTI results were longitudinally analyzed using a tract‐specific analysis to measure the fractional anisotropy ( FA ) values of the entire corpus callosum ( CC ), as well as its genu, trunk, and splenium. Results During the 52‐week study period, seven patients developed psychosis ( ARMS‐P ) and 39 did not ( ARMS‐NP ). In the entire CC and the genu, trunk, and splenium of the CC , the FA values of the ARMS subjects were each significantly smaller than the respective values of the healthy controls at baseline. In the genu and trunk, the baseline FA values in the ARMS‐NP group were, paradoxically, smaller than those of the ARMS‐P group at baseline. Regarding the association between the FA values and psychiatric symptoms, a reduction in the FA value in the genu was significantly correlated with a deterioration of negative symptoms among the ARMS subjects. Conclusion Abnormal white matter integrity in the CC may predict the long‐term outcome of patients with prodromal psychosis, since negative symptoms are associated with poor functioning.