Premium
Simultaneous resting‐state functional MRI and electroencephalography recordings of functional connectivity in patients with schizophrenia
Author(s) -
Kirino Eiji,
Tanaka Shoji,
Fukuta Mayuko,
Inami Rie,
Arai Heii,
Inoue Reiichi,
Aoki Shigeki
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12495
Subject(s) - electroencephalography , default mode network , functional magnetic resonance imaging , schizophrenia (object oriented programming) , resting state fmri , magnetic resonance imaging , prefrontal cortex , neuroscience , psychology , audiology , population , medicine , cognition , psychiatry , radiology , environmental health
Aim It remains unclear how functional connectivity ( FC ) may be related to specific cognitive domains in neuropsychiatric disorders. Here we used simultaneous resting‐state functional magnetic resonance imaging (rsf MRI ) and electroencephalography ( EEG ) recording in patients with schizophrenia, to evaluate FC within and outside the default mode network ( DMN ). Methods Our study population included 14 patients with schizophrenia and 15 healthy control participants. From all participants, we acquired rsf MRI data, and simultaneously recorded EEG data using an MR ‐compatible amplifier. We analyzed the rsf MRI‐EEG data, and used the CONN toolbox to calculate the FC between regions of interest. We also performed between‐group comparisons of standardized low‐resolution electromagnetic tomography‐based intracortical lagged coherence for each EEG frequency band. Results FC within the DMN , as measured by rsf MRI and EEG , did not significantly differ between groups. Analysis of rsf MRI data showed that FC between the right posterior inferior temporal gyrus and medial prefrontal cortex was stronger among patients with schizophrenia compared to control participants. Conclusion Analysis of FC within the DMN using rsf MRI and EEG data revealed no significant differences between patients with schizophrenia and control participants. However, rsf MRI data revealed over‐modulated FC between the medial prefrontal cortex and right posterior inferior temporal gyrus in patients with schizophrenia compared to control participants, suggesting that the patients had altered FC , with higher correlations across nodes within and outside of the DMN . Further studies using simultaneous rsf MRI and EEG are required to determine whether altered FC within the DMN is associated with schizophrenia.