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Altered serum level of matrix metalloproteinase‐9 and its association with decision‐making in eating disorders
Author(s) -
Matsumoto Junko,
Hirano Yoshiyuki,
Hashimoto Kenji,
Ishima Tamaki,
Kanahara Nobuhisa,
Niitsu Tomihisa,
Shiina Akihiro,
Hashimoto Tasuku,
Sato Yasunori,
Yokote Koutaro,
Murano Shunichi,
Kimura Hiroshi,
Hosoda Yutaka,
Shimizu Eiji,
Iyo Masaomi,
Nakazato Michiko
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12490
Subject(s) - anorexia nervosa , iowa gambling task , medicine , psychology , brain derived neurotrophic factor , pathophysiology , eating disorders , bulimia nervosa , anxiety , matrix metalloproteinase 9 , endocrinology , neurotrophic factors , clinical psychology , psychiatry , matrix metalloproteinase , cognition , receptor
Aim The aims of this study were to determine whether the serum levels of precursor brain‐derived neurotrophic factor (pro BDNF ), mature BDNF (m BDNF ), and matrix metalloproteinase‐9 ( MMP ‐9) are altered in patients with eating disorders ( ED ), including anorexia nervosa ( AN ) and bulimia nervosa ( BN ), and to explore whether those levels are associated with decision‐making abilities. Methods Nineteen women with AN , 28 women with BN , and 22 age‐matched healthy control women ( HC ) were enrolled in the current study. All participants had their decision‐making abilities assessed using the Iowa Gambling Task ( IGT ). Their eating‐related pathophysiology and depressive/anxiety symptoms were also evaluated. Results The MMP ‐9 level in AN was significantly lower than that in either BN or HC , but the serum levels of pro BDNF and m BDNF did not differ among the three groups. Investigation of the serum levels of pro BDNF and MMP ‐9 in patients with ED and controls revealed a significant correlation between them. In the BN , there were positive correlations between m BDNF level and IGT performance and also between MMP‐9 level and IGT performance, but these correlations did not occur in AN . The MMP ‐9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN . Conclusion These results suggest that the serum level of MMP ‐9 plays a role in the pathophysiology of AN , and both the serum levels of m BDNF and MMP ‐9 may be associated with decision‐making abilities in patients with BN .