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Prevalence and clinical correlates of flunitrazepam‐related complex sleep behaviors
Author(s) -
Tsai JuiKang,
Yen ChiaNan,
Chen ChengSheng,
Hwang TzungJeng,
Chen ShaoTsu,
Chen TzuTing,
Ko ChihHung,
Su PoWen,
Chang YuPing,
Lin JinJia,
Yen ChengFang
Publication year - 2017
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12472
Subject(s) - flunitrazepam , logistic regression , odds ratio , confidence interval , medicine , alcohol use disorder , psychiatry , alcohol , benzodiazepine , biology , biochemistry , receptor
Aim Complex sleep behaviors ( CSB ) are often associated with the use of hypnotic drugs. This study investigated the prevalence and correlates of CSB among psychiatric patients who were given flunitrazepam. Methods From J une 2011 to M ay 2012, a total of 268 psychiatric outpatients who had received flunitrazepam for at least 3 months were enrolled. Data on occurrence of CSB , demographic characteristics, flunitrazepam dosage and duration of use, psychiatric diagnoses, physical illnesses, and alcohol use were collected. Logistic regression analysis was used to examine the clinical correlates of CSB . Results Sixty‐six participants (24.6%) reported experiencing CSB . Logistic regression analysis showed that a high dosage (>2 mg/day) of flunitrazepam (odds ratio [ OR ] = 1.941, 95% confidence interval [ CI ] = 1.090–3.455, P = 0.024) and alcohol use ( OR = 1.948, 95%CI = 1.023–3.709, P = 0.042) were significantly associated with the occurrence of CSB . Sex, age, duration of flunitrazepam use, psychiatric diagnoses, and physical illnesses were not significantly associated with the occurrence of CSB . Conclusion CSB among flunitrazepam users should be monitored routinely, especially among those receiving a high dosage who also consume alcohol.