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Altered resting‐state functional organization within the central executive network in obsessive–compulsive disorder
Author(s) -
Chen Yunhui,
Meng Xin,
Hu Qiang,
Cui Hongsheng,
Ding Yongzhuo,
Kang Lu,
Juhás Michal,
Greenshaw Andrew J.,
Zhao Ameng,
Wang Yuhua,
Cui Guangcheng,
Li Ping
Publication year - 2016
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12419
Subject(s) - orbitofrontal cortex , resting state fmri , functional magnetic resonance imaging , psychology , neuroscience , dorsolateral prefrontal cortex , functional connectivity , prefrontal cortex , default mode network , executive functions , cognition , audiology , medicine
Aim Obsessive–compulsive disorder ( OCD ) is associated with deficits in response inhibition and planning, which are governed by the central executive network. The objective of this study was to investigate both intra‐ and inter‐regional resting‐state connectivity within the central executive network in OCD . Methods Thirty OCD patients and 30 matched healthy controls were scanned using resting‐state functional magnetic resonance imaging. The independent component analysis was used on a separate sample of healthy controls to generate the central executive network mask for the subsequent OCD analyses. Regional homogeneity ( ReHo ) and seed‐based functional connectivity analyses were used to explore the differences between intra‐ and inter‐regional synchronized activity within the central executive network in OCD patients at rest. Results Increased ReHo and functional connectivity in the key regions of the central executive network, such as the orbitofrontal cortex, dorsolateral prefrontal cortex, and the angular gyrus, were found in OCD patients. Furthermore, changes in both the ReHo within the orbitofrontal cortex and the functional connectivity between the orbitofrontal cortex and angular gyrus were negatively correlated with OCD duration. Conclusion The increased resting‐state functional organization within the central executive network may be related to OCD patients’ deficits in cognitive control and symptom progression.