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Magnetoencephalographic recording of auditory mismatch negativity in response to duration and frequency deviants in a single session in patients with schizophrenia
Author(s) -
Suga Motomu,
Nishimura Yukika,
Kawakubo Yuki,
Yumoto Masato,
Kasai Kiyoto
Publication year - 2016
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12397
Subject(s) - mismatch negativity , magnetoencephalography , psychology , schizophrenia (object oriented programming) , audiology , auditory cortex , psychosis , electroencephalography , neuroscience , medicine , psychiatry
Aim Auditory mismatch negativity ( MMN ) and its magnetoencephalographic ( MEG ) counterpart ( MMNm ) are an established biological index in schizophrenia research. MMN in response to duration and frequency deviants may have differential relevance to the pathophysiology and clinical stages of schizophrenia. MEG has advantage in that it almost purely detects MMNm arising from the auditory cortex. However, few previous MEG studies on schizophrenia have simultaneously assessed MMNm in response to duration and frequency deviants or examined the effect of chronicity on the group difference. Methods Forty‐two patients with chronic schizophrenia and 74 matched control subjects participated in the study. Using a whole‐head MEG , MMNm in response to duration and frequency deviants of tones was recorded while participants passively listened to an auditory sequence. Results Compared to healthy subjects, patients with schizophrenia exhibited significantly reduced powers of MMNm in response to duration deviant in both hemispheres, whereas MMNm in response to frequency deviant did not differ between the two groups. These results did not change according to the chronicity of the illness. Conclusion These results, obtained by using a sequence‐enabling simultaneous assessment of both types of MMNm , suggest that MEG recording of MMN in response to duration deviant may be a more sensitive biological marker of schizophrenia than MMN in response to frequency deviant. Our findings represent an important first step towards establishment of MMN as a biomarker for schizophrenia in real‐world clinical psychiatry settings.