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Intact neural activity during a Go/No‐go task is associated with high global functioning in schizophrenia
Author(s) -
Araki Tsuyoshi,
Kirihara Kenji,
Koshiyama Daisuke,
Nagai Tatsuya,
Tada Mariko,
Fukuda Masato,
Kasai Kiyoto
Publication year - 2016
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12389
Subject(s) - schizophrenia (object oriented programming) , go/no go , psychology , event related potential , task (project management) , audiology , neural activity , global assessment of functioning , electroencephalography , cognitive psychology , neuroscience , psychiatry , clinical psychology , medicine , computer science , management , machine learning , economics
Aim Go/No‐go derived event‐related potential ( ERP ) signals have been widely used in schizophrenia research to monitor self‐control deficits in this disorder. However, no study to date has associated Go/No‐go‐related ERP with global functioning. Methods Participants consisted of 21 patients with schizophrenia and 22 healthy controls. We used a visual Go/No‐go paradigm to measure Go/No‐go‐related N2/P3 ERP components by means of a 64‐electrode cap for electroencephalogram recording. We used the Global Assessment of Functioning to evaluate global functioning and analyzed the correlation between ERP indices and global functioning scores. Results N2 amplitudes were reduced in patients with schizophrenia, but not influenced by either of the Go/No‐go conditions. P3 amplitudes were influenced by the Go/No‐go conditions, but not reduced in patients with schizophrenia. Global functioning was correlated with the No‐go P3 amplitudes, but not N2 amplitudes, in patients with schizophrenia. Conclusion These results indicate that global functioning is associated with intact neural activity rather than impaired neural activity during Go/No‐go response inhibition tasks in patients with schizophrenia.