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Effects of NRG1 genotypes on orbitofrontal sulcogyral patterns in Japanese patients diagnosed with schizophrenia
Author(s) -
Yoshimi Asuka,
Suda Akira,
Hayano Fumi,
Nakamura Motoaki,
AoyamaUehara Kumi,
Konishi Jun,
Asami Takeshi,
Kishida Ikuko,
Kawanishi Chiaki,
Inoue Tomio,
McCarley Robert W.,
Shenton Martha E.,
Hirayasu Yoshio
Publication year - 2016
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12384
Subject(s) - orbitofrontal cortex , single nucleotide polymorphism , schizophrenia (object oriented programming) , snp , genotype , medicine , allele , biology , psychiatry , prefrontal cortex , genetics , cognition , gene
Aim Numerous reports have described differences in the distribution of orbitofrontal cortex ( OFC ) sulcogyral patterns between patients with schizophrenia ( SZ patients) and healthy controls ( HC ). Alterations in OFC morphology are also observed in those at high risk for developing SZ and in first‐episode SZ , suggesting that genetic associations may be extant in determining OFC sulcogyral patterns. We investigated the association between single nucleotide polymorphisms ( SNP ) in NRG1 and OFC sulcogyral patterns. Methods A total of 59 Japanese patients diagnosed with SZ and 60 HC were scanned on a 1.5‐T magnet. Patients were also assessed clinically. OFC sulcogyral patterns were evaluated for each participant, and genotyping was performed for four SNP in NRG1 ( SNP8NRG243177 , SNP8NRG221533 , SNP8NRG241930 , and rs1081062 ) . Results There were significant differences in the distribution of OFC sulcogyral patterns between SZ patients and HC (χ 2 = 6.52, P = 0.038). SZ patients showed an increase in the frequency of Type III expression, which was associated with an earlier age of disease onset (β = −0.302, F = 4.948, P = 0.030). Although no difference was found in genotype frequencies between SZ patients and HC , an NRG1 SNP , SNP8NRG243177 , was associated with Type II expression in SZ patients (β = 0.237, F = 4.120, P = 0.047). Conclusion Our results suggest that OFC sulcogyral pattern formation in schizophrenia may be associated with NRG1 allele frequency, which is closely related to neurodevelopment.

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