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Magnetoencephalography study of the effect of attention modulation on somatosensory processing in patients with major depressive disorder
Author(s) -
Kurita Sumie,
Takei Yuichi,
Maki Yohko,
Hattori Suguru,
Uehara Toru,
Fukuda Masato,
Mikuni Masahiko
Publication year - 2016
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12361
Subject(s) - magnetoencephalography , somatosensory system , psychology , neuroscience , audiology , somatosensory evoked potential , major depressive disorder , modulation (music) , cognitive psychology , medicine , clinical psychology , mood , electroencephalography , art , aesthetics
Aims Although affective and/or attention modulation of somatosensory processing has been well studied, the biological bases of somatic symptoms in patients with major depressive disorder ( MDD ) have rarely been examined. To elucidate changes in somatosensory processing underlying somatic symptoms in patients with MDD , we conducted a magnetoencephalography study of patients with MDD and healthy controls. Methods After median nerve stimulation, somatosensory evoked fields ( SEF ) were recorded in 10 patients with MDD and 10 sex‐, age‐, and height‐matched healthy volunteers under somatosensory attending, visually attending, and non‐attending conditions. The latencies and magnitudes of N 20m and P 60m SEF were examined. Results In the MDD group, P60m latency was significantly prolonged, irrespective of attention modulation, whereas N 20m latency and root mean squares N 20m and P 60m amplitudes remained unchanged. Prolonged P 60m latency negatively correlated with the somatosensory threshold, which was relatively high in the MDD group. Prolonged P60m latency also negatively correlated with a state of anxiety during the examination, but not with depressive symptoms or psychotropic medication. Conclusions These results suggested that patients with MDD experience dysfunction in somatosensory information processing, approximately 60 ms after stimuli, irrespective of attentional conditions.