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Relationships among medication adherence, insight, and neurocognition in chronic schizophrenia
Author(s) -
Na Euihyeon,
Yim Seon Jin,
Lee JoonNoh,
Kim Jung Min,
Hong Kyungki,
Hong MoonHwa,
Han Hyeree
Publication year - 2015
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12272
Subject(s) - neurocognitive , schizophrenia (object oriented programming) , medication adherence , rating scale , medicine , brief psychiatric rating scale , psychiatry , clinical psychology , psychology , psychosis , cognition , developmental psychology
Aims In order to improve long‐term prognosis in schizophrenia, enhancing medication adherence is essential. The aim of this study was thus to identify the association between medication non‐adherence and possible risk factors in a large sample of patients with chronic schizophrenia. Methods One hundred and four patients with schizophrenia with a disease duration of over 10 years were enrolled in this cross‐sectional study. The subjects were assessed with the Scale to Assess Unawareness of Mental Disease– K orean version, the K orean version of the Medication Adherence Rating Scale, a neurocognition battery designed for this study, and the Positive and Negative Symptoms Scale. An anova and multiple regression models were conducted to identify the correlations among variables and the factors that contribute to medication adherence. Results The adherence score measured on the K orean version of the Medication Adherence Rating Scale was 7.60 ± 2.12; 88 (84.62%) patients were categorized as well‐adherent and 16 (15.38%) as poorly adherent to their medication. Patients with good insight were more likely to maintain their medication ( P = 0.0005), and better executive function was associated with increased medication adherence ( P = 0.0008). Furthermore, fewer depressive symptoms were associated with good medication adherence ( P = 0.0304). Conclusions This study is the first in the R epublic of K orea to identify the relationship between medication adherence, insight, and neurocognition in a large sample of patients with chronic schizophrenia. These results could be used to establish a strategy for improving the prognosis of chronic schizophrenia.