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Biological heterogeneity of obsessive–compulsive disorder: A voxel‐based morphometric study based on dimensional assessment
Author(s) -
Okada Kayo,
Nakao Tomohiro,
Sanematsu Hirokuni,
Murayama Keitaro,
Honda Shinichi,
Tomita Mayumi,
Togao Osamu,
Yoshiura Takashi,
Kanba Shigenobu
Publication year - 2015
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12269
Subject(s) - orbitofrontal cortex , voxel based morphometry , voxel , neuroimaging , insula , psychology , obsessive compulsive , magnetic resonance imaging , anterior cingulate cortex , neuroscience , prefrontal cortex , medicine , clinical psychology , white matter , radiology , cognition
Aim Although many neuroimaging studies of obsessive–compulsive disorder ( OCD ) have reported broad abnormalities in gray matter ( GM ), their results remain inconsistent. One reason for this inconsistency could be the heterogeneity of OCD . In the present study, we aimed to classify alterations in brain anatomy by OCD subtype. Methods Magnetic resonance imaging examinations of 37 OCD patients and 37 matched healthy controls were conducted using a 3.0‐ T esla scanner. In the voxel‐based morphometric procedure, preprocessed GM structural images were used to compare the two groups, and multiple regression analysis was used to investigate the correlation between regional GM volume in OCD patients and the OCD symptom dimension type assessed by using the D imensional Y ale– B rown O bsessive– C ompulsive S cale. Results We found significant reductions in GM volume in broad areas of the left prefrontal, right orbitofrontal, right parietal, right temporal, and right posterior cingulate cortex in the OCD patients compared to healthy controls. In addition, we found specific negative correlations between symptomatic dimension scores and regional GM volumes, mainly as decreased right cerebellum in ‘aggression/checking’ and decreased right insula in ‘contamination/washing’. Conclusion The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.