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Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention‐deficit/hyperactivity disorder as measured by near‐infrared spectroscopy
Author(s) -
Ota Toyosaku,
Iida Junzo,
Nakanishi Yoko,
Sawada Satomi,
Matsuura Hiroki,
Yamamuro Kazuhiko,
Ueda Shotaro,
Uratani Mitsuhiro,
Kishimoto Naoko,
Negoro Hideki,
Kishimoto Toshifumi
Publication year - 2015
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12251
Subject(s) - atomoxetine , stroop effect , atomoxetine hydrochloride , prefrontal cortex , attention deficit hyperactivity disorder , psychology , hemodynamics , anesthesia , functional near infrared spectroscopy , psychiatry , audiology , medicine , methylphenidate , cognition
Aim Atomoxetine, approved in J apan for the treatment of pediatric attention‐deficit/hyperactivity disorder ( ADHD ) in A pril 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near‐infrared spectroscopy is a non‐invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD , as measured by near‐infrared spectroscopy using the S troop Color–Word Task. Methods Ten children with ADHD participated in the present study. We used 24‐channel near‐infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug‐naïve condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1 s during the S troop Color–Word Task. We used the ADHD R ating S cale‐ IV ‐ J apanese version ( H ome V ersion) to evaluate ADHD symptoms.Results We found a significant decrease in ADHD R ating S cale‐ IV ‐ J apanese version scores, from 30.7 to 22.6 ( P = 0.003). During the S troop Color–Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug‐naïve condition. Conclusions This increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near‐infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD .