Latest concept of L ewy body disease

We proposed the term ‘ L ewy body disease’ ( LBD ) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of L ewy bodies: a brainstem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have proposed since 1980, LBD has recently been used as a generic term, including Parkinson's disease, P arkinson's disease with dementia and dementia with L ewy bodies. LBD has neuropathological characteristics whereby numerous L ewy bodies are present in the central and sympathetic nervous systems, and it is a type of alpha‐synucleinopathy because the main component of L ewy body is alpha‐synuclein. In this paper we explain the most recent concept of LBD from the historical viewpoint.