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Prevalence of depression symptoms and serum levels of interleukin‐6 in hemodialysis patients
Author(s) -
Knuth Berenice,
Radtke Vinícius,
Rocha Pablo,
Silva Kátia Sulenir,
Dalsóglio Fabiana,
Gazal Marta,
Jansen Karen,
Souza Diogo Onofre,
Portela Luis Valmor,
Kaster Manuella,
Oses Jean Pierre
Publication year - 2014
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12130
Subject(s) - hemodialysis , depression (economics) , beck depression inventory , medicine , dialysis , psychopathology , gastroenterology , kidney disease , interleukin 6 , inflammation , psychiatry , anxiety , economics , macroeconomics
Aim In hemodialysis patients, depression appears as the most common psychopathological condition. States of advanced chronic kidney disease and dialysis are associated with a state of chronic inflammation. Depression has been linked to activation of the immune system characterized by high levels of pro‐inflammatory cytokines. In this study, we investigated the possible correlations between depression, and interleukin‐6 ( IL ‐6) in hemodialysis patients. Methods Seventy‐five hemodialysis patients were enrolled in a cross‐sectional study from S eptember to N ovember 2011 in P elotas, Rio Grande do Sul. Demographic data were obtained from a questionnaire and the Beck Depression Inventory ( BDI ) was used to determine the presence or absence of depression symptoms. Biochemical parameters, dialysisdosage delivery, and IL ‐6 serum levels were measured. Results Prevalence of depression among hemodialysis patients was 48% ( BDI ≥ 14). In biochemical assessments, depressed patients showed a decrease in urea ( P = 0.01) and increase of IL ‐6 ( P = 0.04) levels. The correlation analysis between BDI scores and the biochemical variables showed that BDI was negatively correlated with urea ( P = 0.03) and potassium ( P = 0.04), but not with IL ‐6 levels. Conclusion Hemodialysis patients with depression showed higher levels of IL ‐6 but the severity of depressive symptoms was not correlated with levels of this cytokine.