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Review of neurophysiological findings in patients with schizophrenia
Author(s) -
Onitsuka Toshiaki,
Oribe Naoya,
Nakamura Itta,
Kanba Shigenobu
Publication year - 2013
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12090
Subject(s) - n100 , schizophrenia (object oriented programming) , magnetoencephalography , sensory gating , neurophysiology , psychology , neuroscience , mismatch negativity , electroencephalography , n400 , psychosis , cognition , audiology , gating , event related potential , psychiatry , medicine
Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry have been proposed as a basis for this disorder. In this article, we focus on electroencephalography and magnetoencephalography findings in patients with schizophrenia. Auditory‐ P50 , ‐ N100 , and ‐ P300 findings, visual‐ P100 , ‐ N170 , and ‐ N400 findings, and neural oscillations in patients with schizophrenia are overviewed. Published results suggest that patients with schizophrenia have neurophysiological deficits from the very early phase of sensory processing (i.e. P50 , P100 , N100 ) to the relatively late phase (i.e. P300 , N400 ) in both auditory and visual perception. Exploring the associations between neural substrates, including neurotransmitter systems, and neurophysiological findings, will lead to a more comprehensive understanding of the pathophysiology of schizophrenia.