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Association of the BDNF C270T polymorphism with schizophrenia: Updated meta‐analysis
Author(s) -
Watanabe Yuichiro,
Nunokawa Ayako,
Someya Toshiyuki
Publication year - 2013
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12018
Subject(s) - schizophrenia (object oriented programming) , brain derived neurotrophic factor , allele , meta analysis , polymorphism (computer science) , genetic association , population , neurotrophic factors , psychology , medicine , genetics , single nucleotide polymorphism , biology , genotype , receptor , psychiatry , gene , environmental health
Brain‐derived neurotrophic factor ( BDNF ) has been suggested to play a role in the pathophysiology of schizophrenia. The C270T polymorphism (rs56164415) in the BDNF 5′‐non‐coding region has been extensively investigated for an association with schizophrenia, but with conflicting results. An updated meta‐analysis was therefore performed of 13 case–control association studies (3505 patients and 3992 controls). An association was found between the T allele and schizophrenia. The association was significant in the E ast A sian population, but not in the C aucasian population. It is suggested that the BDNF C270T polymorphism contributes to schizophrenia susceptibility, especially in E ast A sian subjects.