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Correlations between atrophy of the entorhinal cortex and cognitive function in patients with A lzheimer's disease and mild cognitive impairment
Author(s) -
Li Xudong,
Jiao Jinsong,
Shimizu Satoru,
Jibiki Itsuki,
Watanabe Kenichiro,
Kubota Takashi
Publication year - 2012
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/pcn.12002
Subject(s) - wechsler adult intelligence scale , entorhinal cortex , neuropsychology , atrophy , dementia , psychology , cognition , frontotemporal dementia , alzheimer's disease , neuropsychological test , audiology , neuroscience , medicine , disease , clinical psychology , hippocampus
Aims In order to confirm the utility of the voxel‐based specific regional analysis system for A lzheimer's disease ( VSRAD ) in assessing the atrophy of the entorhinal cortex, we investigated whether there were correlations between VSRAD and the scores of neuropsychological tests in the patients with A lzheimer's disease ( AD ) and mild cognitive impairment. Methods Thirty patients, including 18 AD and 12 mild cognitive impairment patients, were included in this study. VSRAD was performed to assess the atrophy of the entorhinal cortex. The patients were carefully screened with the neuropsychological tests, including W echsler A dult I ntelligence S cale‐ III ( WAIS‐III ), the W echsler M emory S cale‐ R evised, the A lzheimer's D isease A ssessment S cale‐Cognitive Part ( ADAS ‐cog) and the revised version of H asegawa's D ementia S cale. Results All patients showed atrophy with different degrees in the entorhinal cortex except one case. Z ‐scores had significant positive correlation with ADAS ‐cog, and negative correlation with Information subset of WAIS‐III (respectively, P = 0.0129 and P = 0.0294). The revised version of H asegawa's D ementia S cale and the Similarities subsets of the WAIS‐III had a tendency of negatively correlating with Z ‐scores of VSRAD (respectively, P = 0.0532 and P = 0.0635). The D elayed V isual R eproduction subset of the W echsler M emory S cale‐ R evised was also found to have a weak negative correlation with Z ‐scores ( P = 0.0609). Conclusions Z ‐scores of VSRAD were revealed to have a close relation with many neuropsychological tests, especially ADAS ‐cog and the Information subset of WAIS‐III . The results meant that VSRAD was a useful indictor of early diagnosis of AD , closely correlating with the changes of cognitive functions and the progression of the disease.