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Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome
Author(s) -
Roy Simon F.,
Bastian Boris C.,
Maguiness Sheilagh,
Giubellino Alessio,
Vemula Swapna S.,
McCalmont Timothy H.,
Yeh Iwei
Publication year - 2021
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12963
Subject(s) - spitz nevus , ring chromosome , ring (chemistry) , chromosome , medicine , dermatology , biology , pathology , cancer research , genetics , nevus , melanoma , karyotype , gene , chemistry , organic chemistry
Patients with non‐supernumerary ring chromosome 7 syndrome have an increased incidence of hemangiomas, café‐au‐lait spots, and melanocytic nevi. The mechanism for the increased incidence of these benign neoplasms is unknown. We present the case of a 22‐year‐old man with ring chromosome 7 and multiple melanocytic nevi. Two nevi, one on the right ear and the other on the right knee, were biopsied and diagnosed as desmoplastic Spitz nevi. Upon targeted next‐generation DNA sequencing, both harbored BRAF fusions. Copy number alterations and fluorescence in situ hybridization (FISH) for BRAF suggested that the fusions arose on the ring chromosome 7. Hence, one reason for increased numbers of nevi in patients with non‐supernumerary ring chromosome 7 syndrome may be increased likelihood of BRAF fusions, due to the instability of the ring chromosome.