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Making a melanoma: Molecular and cellular changes underlying melanoma initiation
Author(s) -
Darp Revati,
Ceol Craig
Publication year - 2021
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12950
Subject(s) - melanoma , melanocyte , lineage (genetic) , cancer research , biology , skin cancer , cancer , computational biology , genetics , gene
Melanoma arises from the melanocyte lineage and is the most aggressive and lethal form of skin cancer. There are several genetic, genomic, and cellular changes associated with melanoma initiation. Here, we discuss these alterations and the melanoma cells of origin in which they are proposed to promote melanomagenesis.