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Regulation of melanocyte stem cell behavior by the niche microenvironment
Author(s) -
Li Huirong,
Hou Ling
Publication year - 2018
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12701
Subject(s) - stem cell , microbiology and biotechnology , wnt signaling pathway , biology , crosstalk , niche , stem cell niche , melanocyte , signal transduction , progenitor cell , genetics , ecology , melanoma , physics , optics
Summary Somatic stem cells are regulated by their niches to maintain tissue homeostasis and repair throughout the lifetime of an organism. An excellent example to study stem cell/niche interactions is provided by the regeneration of melanocytes during the hair cycle and in response to various types of injury. These processes are regulated by neighboring stem cells and multiple signaling pathways, including WNT /β‐catenin, KITL / KIT , EDN s/ EDNRB , TGF ‐β/ TGF ‐βR, α‐ MSH / MC 1R, and Notch signaling. In this review, we highlight recent studies that have advanced our understanding of the molecular crosstalk between melanocyte stem cells and their neighboring cells, which collectively form the niche microenvironment, and we focus on the question of how Mc SC s/niche interactions shape the responses to genotoxic damages and mechanical injury.

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