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The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
Author(s) -
Orlow Irene,
Shi Yang,
Kanetsky Peter A.,
Thomas Nancy E.,
Luo Li,
CorralesGuerrero Sergio,
Cust Anne E.,
Sacchetto Lidia,
Zanetti Roberto,
Rosso Stefano,
Armstrong Bruce K.,
Dwyer Terence,
Venn Alison,
Gallagher Richard P.,
Gruber Stephen B.,
Marrett Loraine D.,
AntonCulver Hoda,
Busam Klaus,
Begg Colin B.,
Berwick Marianne
Publication year - 2018
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12653
Subject(s) - taqi , calcitriol receptor , melanoma , snp , haplotype , medicine , vitamin d and neurology , oncology , sunburn , cancer research , genotype , single nucleotide polymorphism , polymorphism (computer science) , biology , genetics , gene , dermatology
Summary Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene ( VDR ) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNP s and a common 3′‐end haplotype were significant ( p < .05). These SNP s, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB . SNP s rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma‐specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.