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Micro holes for delivering melanocytes into the skin: an ex vivo approach
Author(s) -
Regazzetti Claire,
Alcor Damien,
ChigSicard Bérengère,
Passeron Thierry
Publication year - 2016
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12492
Subject(s) - ex vivo , computer science , content (measure theory) , in vivo , computational biology , microbiology and biotechnology , world wide web , biology , genetics , mathematics , mathematical analysis
Vitiligo affects 0.5% of the population worldwide. Among available treatments, surgical grafts are indicated for segmental vitiligo and stable and localized forms of non-segmental vitiligo (Ezzedine et al., 2015; van Geel et al., 2010). The procedure for preparing the grafting bed requires a dermabrasion that can be done surgically or by using an ablative laser. These techniques are relatively painful and require a trained physician with an adapted platform preventing many patients to benefit from cell grafting. Micro holes performed using micro needles, erbium or CO2 fractional ablative lasers have been shown to enhance the penetration of topical agents, such as methyl ALA used in photodynamic therapy (Bahadoran et al., 2015; Haedersdal et al., 2010) This article is protected by copyright. All rights reserved.