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Histone variants and melanoma: facts and hypotheses
Author(s) -
Konstantinov Nikifor K.,
UlffMøller Constance J.,
Dimitrov Stefan
Publication year - 2016
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12467
Subject(s) - epigenetics , epigenomics , histone , melanoma , chromatin , biology , epigenesis , disease , computational biology , cancer research , genetics , medicine , bioinformatics , dna methylation , gene , gene expression
Summary Melanoma is the most aggressive form of skin cancer with rising incidence and morbidity. Despite advances in treatment, the 10‐yr survival for patients with metastatic disease is less than 10%. During the past few years, ongoing research on different epigenomic aberrations in melanoma has catalyzed better understanding of its pathogenesis and identification of new therapeutics. In our review, we will focus on the role of histone variants, key epigenetic players in melanoma initiation and progression. Specifically, incorporation of histone variants enables additional layers of chromatin structure, and here, we will describe how alterations in this epigenetic behavior impact melanoma.