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MITF is a critical regulator of the carcinoembryonic antigen‐related cell adhesion molecule 1 ( CEACAM 1) in malignant melanoma
Author(s) -
Ullrich Nico,
Löffek Stefanie,
Horn Susanne,
Ennen Marie,
SánchezdelCampo Luis,
Zhao Fang,
Breitenbuecher Frank,
Davidson Irwin,
Singer Bernhard B.,
Schadendorf Dirk,
Goding Colin R.,
Helfrich Iris
Publication year - 2015
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12414
Subject(s) - carcinoembryonic antigen , microphthalmia associated transcription factor , melanoma , regulator , cancer research , cell adhesion molecule , medicine , biology , chemistry , microbiology and biotechnology , cancer , transcription factor , genetics , gene
Summary The multifunctional I g‐like carcinoembryonic antigen‐related cell adhesion molecule 1 ( CEACAM 1) is neo‐expressed in the majority of malignant melanoma lesions. CEACAM 1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how CEACAM 1 expression is regulated is largely unknown. Here, we show that CEACAM 1 expression in melanoma cell lines and melanoma tissue strongly correlates with that of the microphthalmia‐associated transcription factor ( MITF ), a key regulator of melanoma proliferation and invasiveness. MITF is revealed as a direct and positive regulator for CEACAM 1 expression via binding to an M ‐box motif located in the CEACAM 1 promoter. Taken together, our study provides novel insights into the regulation of CEACAM 1 expression and suggests an MITF ‐ CEACAM 1 axis as a potential determinant of melanoma progression.
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