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Analysis of melanoma‐related micro RNA s expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs
Author(s) -
Baco Michael,
Chu Chiaying,
Bouet Stephan,
RogelGaillard Claire,
Bourneuf Emmanuelle,
Le Provost Fabienne,
Chu ChiaYu,
VincentNaulleau Silvia
Publication year - 2014
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12243
Subject(s) - biology , microbiology and biotechnology
Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma biology are required. MicroRNAs (miRNAs) represent an emerging field in melanoma understanding. These small regulators of gene expression, involved in melanoma development and progression (Da cruz et al., 2012), showed promising results as biomarkers (Nair et al., 2012). As each miRNA could regulate multiple protein-coding genes and conversely, one gene could be targeted by different miRNAs (Bartel et al., 2009), the dysregulation of miRNAs could significantly impact various pathways and cells behavior