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Acute exposure to ultraviolet‐B radiation modulates sex steroid hormones and receptor expression in the skin and may contribute to the sex bias of melanoma in a fish model
Author(s) -
Mitchell David L.,
Fernandez André A.,
Garcia Rachel,
Paniker Lakshmi,
Lin Kevin,
Hanninen Amanda,
Zigelsky Kyle,
May Matthew,
Nuttall Mark,
Lo HerngHsiang,
Person Maria D.,
Earley Ryan
Publication year - 2014
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12213
Subject(s) - hormone , endocrinology , medicine , testosterone (patch) , melanoma , biology , receptor , steroid , steroid hormone , skin cancer , sex hormone receptor , cancer , cancer research , estrogen receptor , breast cancer
Summary Using the X iphophorus fish melanoma model, we show a strong male bias for sunlight‐induced malignant melanoma, consistent with that seen in the human population. To examine underlying factors, we exposed adult X . couchianus fish to a single, sublethal dose of UVB and measured circulating sex steroid hormones and expression of associated hormone receptor genes over a 24‐h period. We found that a single exposure had profound effects on circulating levels of steroid hormones with significant decreases for all free sex steroids at 6 and 24 h and increases in conjugated 2‐estradiol and 11‐ketotestosterone at 6 and 24 h, respectively. Whereas AR α expression increased in male and female skin, neither AR β nor either of the ER s showed significant responses to UVB in either sex. The rapid response of male androgens and their receptors in the skin after UVB irradiation implicates hormones in the male bias of skin cancer and suggests that the photoendocrine response immediately after UV exposure may be relevant to melanomagenesis.