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Cyclin‐dependent kinases as therapeutic targets in melanoma
Author(s) -
Miller David M.,
Flaherty Keith T.
Publication year - 2014
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12211
Subject(s) - cyclin dependent kinase , mapk/erk pathway , kinase , cancer research , targeted therapy , melanoma , biology , drug discovery , immune checkpoint , cell cycle , microbiology and biotechnology , bioinformatics , immune system , immunology , immunotherapy , cell , cancer , genetics
Summary Decades of scientific insights have led to a recent expansion of the therapeutic menu for melanoma. Despite these advances, the current targeted therapies and immune checkpoint agents continue to yield suboptimal response and cure rates. Hitherto, the most effective targeted therapy strategies have centered on effectors in the mitogen‐activated protein kinase ( MAPK ) pathway. This review focuses on the emerging evidence of combinatorial approaches targeting both MAPK signaling and dysregulations in cell‐cycle checkpoints. We discuss the prospects and limitations of utilizing strategies that promote cellular senescence, such as inhibition of the interphase cyclin‐dependent kinases ( CDK s) and highlight the current state of CDK drug discovery in melanoma.