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Decreased regulatory T ‐cells and CD 4 + / CD 8 + ratio correlate with disease onset and progression in patients with generalized vitiligo
Author(s) -
Dwivedi Mitesh,
Laddha Naresh C.,
Arora Prateek,
Marfatia Yogesh S.,
Begum Rasheedunnisa
Publication year - 2013
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12105
Subject(s) - pathogenesis , cd8 , flow cytometry , foxp3 , regulatory t cell , il 2 receptor , medicine , t cell , immunology , endocrinology , chemistry , microbiology and biotechnology , biology , immune system
Summary The aim of present study was to evaluate CD4 + /CD8 + ratio and CD4 + CD25 hi FoxP3 + Tregs in GV patients with reference to their effect on disease onset and progression. Flow cytometry was used for determination of CD4 + /CD8 + ratio and Tregs in 82 patients and 50 controls. CD8 + T‐cell counts were significantly higher in GV patients as compared with controls (p = 0.003). Active GV patients showed higher CD8 + T‐cell counts compared with stable GV patients (p = 0.001). The CD4 + /CD8 + ratio decreased significantly in patients as compared with controls (p = 0.001). Moreover, the ratio in active GV patients significantly lowered as compared with stable GV patients (p = 0.002). Significant decrease in Treg cell percentage and counts in GV patients was observed compared with controls (p = 0.009, p = 0.008) with significant reduction in FoxP3 expression (p = 0.024). Treg cell percentage and counts were significantly decreased in active GV patients compared with stable GV patients (p = 0.007, p = 0.002). Our results suggest that an imbalance of CD4 + /CD8 + ratio and natural Tregs in frequency and function might be involved in the T‐cell mediated pathogenesis of GV and its progression.