Premium
Type‐ II histone deacetylases: elusive plant nuclear signal transducers
Author(s) -
GRANDPERRET VINCENT,
NICOLASFRANCÈS VALÉRIE,
WENDEHENNE DAVID,
BOURQUE STÉPHANE
Publication year - 2014
Publication title -
plant, cell and environment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.646
H-Index - 200
eISSN - 1365-3040
pISSN - 0140-7791
DOI - 10.1111/pce.12236
Subject(s) - histone acetyltransferases , histone , acetylation , biology , sap30 , microbiology and biotechnology , nuclear protein , signal transduction , nuclear export signal , nuclear localization sequence , computational biology , genetics , cell nucleus , transcription factor , nucleus , histone deacetylase , gene
Since the beginning of the 21st century, numerous studies have concluded that the plant cell nucleus is one of the cellular compartments that define the specificity of the cellular response to an external stimulus or to a specific developmental stage. To that purpose, the nucleus contains all the enzymatic machinery required to carry out a wide variety of nuclear protein post‐translational modifications ( PTMs ), which play an important role in signal transduction pathways leading to the modulation of specific sets of genes. PTMs include protein (de)acetylation which is controlled by the antagonistic activities of histone acetyltransferases ( HATs ) and histone deacetylases ( HDACs ). Regarding protein deacetylation, plants are of particular interest: in addition to the RPD 3‐ HDA 1 and S ir2 HDAC families that they share with other eukaryotic organisms, plants have developed a specific family called type‐ II HDACs ( HD 2s). Interestingly, these HD 2s are well conserved in plants and control fundamental biological processes such as seed germination, flowering or the response to pathogens. The aim of this review was to summarize current knowledge regarding this fascinating, but still poorly understood nuclear protein family.