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A Randomized Double‐Blind Controlled Pilot Study Comparing Leucocyte‐Rich Platelet‐Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal Pain
Author(s) -
RuizLopez Ricardo,
Tsai YuChuan
Publication year - 2020
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/papr.12893
Subject(s) - medicine , triamcinolone acetonide , corticosteroid , platelet rich plasma , lumbar , adverse effect , anesthesia , randomized controlled trial , quality of life (healthcare) , epidural steroid injection , radicular pain , visual analogue scale , low back pain , back pain , surgery , platelet , alternative medicine , nursing , pathology
Objectives To compare the efficacy and safety between leucocyte‐rich platelet‐rich plasma (LR‐PRP) and corticosteroid in fluoroscopically guided caudal epidural injection for patients with complex chronic lumbar spinal pain. Study Design A prospective randomized controlled double‐blinded study. Methods Fifty eligible patients with complex chronic degenerative spinal pain were randomly assigned with a 1:1 allocation ratio to receive caudal epidural injection of corticosteroid (triamcinolone acetonide, 60 mg) or LR‐PRP (isolated from 60 mL autologous blood) under fluoroscopic guidance. Levels of low back pain, quality of life, and complications (or adverse effects) were evaluated at 1, 3, and 6 months after treatment. Pain levels and quality of life were assessed using the VAS and Short Form 36‐Item Health Survey (SF‐36), respectively. Results No significant difference was shown at baseline between the 2 groups. Compared with the pretreatment values, there were significant reductions in the VAS score in both groups. A significantly lower VAS score at 1‐month follow‐up was detected in patients who received corticosteroid injection. However, the scores were lower in the LR‐PRP group at 3‐ and 6‐month follow‐up. SF‐36 responses at 6 months showed significant improvement in all domains in the LR‐PRP group. There were no complications or adverse effects related to treatment at 6‐month follow‐up in either group. Conclusions Both autologous LR‐PRP and corticosteroid for caudal epidural injections under fluoroscopic guidance are equally safe and therapeutically effective in patients with complex chronic lumbar spinal pain. However, LR‐PRP is superior to corticosteroid for a longer pain‐relieving effect and improvement in quality of life.