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A Prospective Study Comparing Platelet‐Rich Plasma and Local Anesthetic (LA) /Corticosteroid in Intra‐Articular Injection for the Treatment of Lumbar Facet Joint Syndrome
Author(s) -
Wu Jiuping,
Zhou Jingjing,
Liu Chibing,
Zhang Jun,
Xiong Wei,
Lv Yang,
Liu Rui,
Wang Ruiqiang,
Du Zhenwu,
Zhang Guizhen,
Liu Qinyi
Publication year - 2017
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/papr.12544
Subject(s) - medicine , oswestry disability index , corticosteroid , visual analogue scale , platelet rich plasma , anesthesia , lumbar , local anesthetic , surgery , randomized controlled trial , facet joint , back pain , low back pain , facet (psychology) , platelet , psychology , social psychology , alternative medicine , personality , pathology , big five personality traits
Abstract Objectives To compare the effectiveness and safety between autologous platelet‐rich plasma ( PRP ) and Local Anesthetic (LA) /corticosteroid in intra‐articular injection for the treatment of lumbar facet joint syndrome. Methods Forty‐six eligible patients with lumbar facet joint syndrome were randomized into group A (intra‐articular injection with PRP ) and group B (intra‐articular injection with LA /corticosteroid). The following contents were evaluated: pain visual analog scale ( VAS ) at rest and during flexion, and the Roland‐Morris Disability Questionnaire ( RMQ ), Oswestry Disability Index ( ODI ), and modified MacNab criteria for pain relief and applications of post‐treatment drugs. All outcome assessments were performed immediately after and at 1 week, 1, 2, 3, and 6 months after treatment. Results No significant difference between groups was observed at baseline. Compared with pretreatment, both group A and group B demonstrated statistical improvements in the pain VAS score at rest or during flexion, the RMQ , and the ODI ( P < 0.01). And there were significant differences between the 2 groups on the above‐mentioned items ( P < 0.05). For group B, subjective satisfaction based on the modified MacNab criteria and objective success rate were highest (80% and 85%) after 1 month, but only 50% and 20% after 6 months. However, for group A, they increased over time. In addition, there were no treatment‐related complications in either group during follow‐up. Conclusions Both autologous PRP and LA /corticosteroid for intra‐articular injection are effective, easy, and safe enough in the treatment of lumbar facet joint syndrome. However, autologous PRP is a superior treatment option for longer duration efficacy.