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Some Non‐ FDA Approved Uses for Neuromodulation: A Review of the Evidence
Author(s) -
Lee Samuel,
AbdElsayed Alaa
Publication year - 2016
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/papr.12405
Subject(s) - medicine , neuromodulation , spinal cord stimulation , clinical trial , peripheral nerve stimulation , coronary artery disease , randomized controlled trial , intensive care medicine , stimulation , surgery
Neuromodulation, including spinal cord stimulation and peripheral nerve field stimulation, has been used with success in treating several painful conditions. The FDA approved the use of neuromodulation for a few indications. We review evidence for neuromodulation in treating some important painful conditions that are not currently FDA approved. Methods This review included an online web search for only clinical trials testing the efficacy of neuromodulation in treating coronary artery disease, peripheral vascular disease ( PVD ), headache, and peripheral field stimulation. Results Our systematic literature search found 10, 6, and 3 controlled studies relating to coronary artery disease, PVD , and headache, respectively. Our review also included 5 noncontrolled studies relating to peripheral field stimulation, as no controlled studies had been completed. Conclusion This review article shows compelling evidence based on clinical trials that neuromodulation can be of benefit for patients with serious painful conditions that are not currently approved by the FDA .