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Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
Author(s) -
Angeletti Chiara,
Guetti Cristiana,
Piroli Alba,
Angeletti Paolo Matteo,
Paladini Antonella,
Ciccozzi Alessandra,
Marinangeli Franco,
Varrassi Giustino
Publication year - 2013
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/papr.12009
Subject(s) - duloxetine , pregabalin , fibromyalgia , medicine , physical therapy , anesthesia , physical medicine and rehabilitation , alternative medicine , pathology
The fibromyalgia syndrome ( FMS ) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno‐rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by “central sensitization,” which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new‐generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.