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Migraine Treated Using a Prophylactic Combination of Candesartan and Hydrochlorothiazide ( ECARD ® Combination Tablets LD )
Author(s) -
Akiyama Hisanao,
Hasegawa Yasuhiro
Publication year - 2013
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/papr.12005
Subject(s) - hydrochlorothiazide , candesartan , medicine , migraine , edema , diuretic , combination therapy , anesthesia , pharmacology , blood pressure , angiotensin ii
We describe the use of the antihypertensive, candesartan, with hydrochlorothiazide ( ECARD ® Combination Tablets LD ) as a preventive therapy that decreased the frequency of migraine accompanied by premonitory leg edema. Two women (aged 26 and 50 years) presented to hospital with an increasing frequency of migraine without aura accompanied by leg edema. We prescribed ECARD ® half tablet (candesartan, 2 mg and hydrochlorothiazide, 3.125 mg), and the migraines and leg edema disappeared. The use of ECARD ® to treat a series of migraines by controlling premonitory leg edema has not been reported. ECARD ® , combined with a low‐dose diuretic, may have been helpful in these patients with the premonitory migraine symptom of leg edema.