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Propofol–ketamine or propofol–remifentanil for deep sedation and analgesia in pediatric patients undergoing burn dressing changes: a randomized clinical trial
Author(s) -
Seol TaiKyung,
Lim JinKyu,
Yoo EunKyung,
Min SeongWon,
Kim ChongSoo,
Hwang JinYoung
Publication year - 2015
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12592
Subject(s) - propofol , remifentanil , medicine , anesthesia , ketamine , sedation , vomiting , adverse effect , surgery
Summary Objective In this study, we compared the propofol–ketamine and propofol–remifentanil combinations for deep sedation and analgesia during pediatric burn wound dressing changes. Methods Fifty pediatric patients aged 12–36 months, undergoing burn wound dressing changes, were randomly assigned to receive propofol–remifentanil (group PR ) or propofol–ketamine (group PK ) for deep sedation and analgesia. Patients in the group PR received 2 mg·kg −1 propofol and 0.1 μg·kg −1 remifentanil, and 0.05 μg·kg −1 ·min −1 remifentanil was infused continuously until the end of the procedure. Patients in the group PK received 2 mg·kg −1 propofol and 1 mg·kg −1 ketamine, and the same volume of isotonic saline was infused continuously until the end of the procedure. Additional propofol with remifentanil or ketamine was administered when required. Hemodynamic variables, drug requirements, occurrence of patient movement, surgeon's satisfaction score, recovery time, and the incidence of adverse events were recorded throughout the procedure and recovery. Results Recovery time was significantly shorter in the group PR compared to that in the group PK (10.3 [9.1–11.5] min vs 22.5 [20.3–25.6] min, median [interquartile range], respectively; P < 0.001). No significant hypotension or bradycardia occurred throughout the procedure. No significant differences were observed in terms of drug requirements, occurrence of patient movement, surgeon's satisfaction, incidence of respiratory depression, hypoxia, or nausea and vomiting Conclusions The combinations of propofol–ketamine and propofol–remifentanil were effective for sedation and analgesia in pediatric patients undergoing burn dressing changes, but the propofol–remifentanil combination provided faster recovery compared to the propofol–ketamine combination.