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Retrospective evaluation of antimicrobial prophylaxis in prevention of surgical site infection in the pediatric population
Author(s) -
Shah Goonjan S.,
Christensen Robert E.,
Wagner Deborah S.,
Pearce Bridget K.,
Sweeney Jennifer,
Tait Alan R.
Publication year - 2014
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12436
Subject(s) - medicine , antibiotics , perioperative , antibiotic prophylaxis , retrospective cohort study , demographics , pediatrics , medical record , surgical site infection , pediatric surgery , surgery , demography , sociology , microbiology and biotechnology , biology
Summary Background and Objectives Few studies have been conducted in pediatric patients evaluating efficacy of prophylactic antibiotics for prevention of surgical site infection ( SSI ). This retrospective study was undertaken to determine the effect of antibiotic prophylaxis in the prevention of SSI in children. Methods With IRB approval, our perioperative electronic clinical information database was queried. Pediatric patients (≤18 years) undergoing general surgery, cardiac surgery, and spinal surgery at Mott Children's Hospital from January 2000 to April 2010 were included. Demographics and preoperative data were obtained from the Centricity Intraoperative Database, and any episodes of SSI were obtained by review of the infection control records. Results A total 5023 pediatric patients underwent surgery from January 2000 to April 2010. The average age of the children in the sample was 4.16 ± 5.5 years, and of these, 57% were boys. Overall, 119 (2.37%) cases of SSI were identified. There were no associations between the various patient factors and the development of SSI s. Children for whom antibiotics were administered incorrectly had a 1.7‐fold increased risk of SSI s compared with children who received antibiotics within the recommended guidelines ( P < 0.02). Children who received antibiotics were more likely to suffer an SSI compared with those who did not. Conclusions Proper administration of preoperative antibiotics in pediatric patients is one of the few modifiable and significant factors in prevention of SSI .