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Sevoflurane‐induced changes in infants' quantifiable electroencephalogram parameters
Author(s) -
McKeever Stephen,
Johnston Linda,
Davidson Andrew J.
Publication year - 2014
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12366
Subject(s) - medicine , sevoflurane , electroencephalography , bispectral index , anesthesia , anesthetic , burst suppression , minimum alveolar concentration , pediatrics , population , sedation , environmental health , psychiatry
Summary Background Electroencephalogram ( EEG ) based depth of anesthesia algorithms developed in the adult population have not demonstrated the same reliability when applied to infants. This may be due to frequency changes occurring in the EEG during development. Amplitude‐integrated EEG ( aEEG ) is based primarily in the time domain and hence may have greater utility in infants. Objective To investigate the relationship between age adjusted Minimal Alveolar Concentration (MAC) multiples and aEEG in children under 2 years of age. Methods The aEEG , Spectral Edge Frequency 90% ( SEF 90) and Bispectral Index™ ( BIS ) were investigated in a prospective study of children <2 years of age. After anesthetic induction, and caudal block administration, EEG data were collected simultaneously with BrainZ BRM 2™ and BIS™ monitors. Using a randomized crossover design, children received up to three age adjusted concentrations of sevoflurane: 0.75, 1 and 1.25 MAC . After 15 min of stable anesthetic delivery EEG readings were obtained. Prediction Probability (P k ) and correlation coefficients were calculated for each EEG parameter. Results From 51 children 102 stable anesthetics concentrations were obtained. For all age groups P k of aEEG to multiple of age adjusted MAC was <0.72 indicating a poor predictive power for aEEG . In contrast for the SEF 90 and BIS there was evidence for better predictive properties in children aged between 6 months and 2 years, with a P k >0.81. Conclusion The aEEG is unlikely to be a useful measure of anesthesia depth in young children.