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Beyond survival; influences of blood pressure, cerebral perfusion and anesthesia on neurodevelopment
Author(s) -
McCann Mary Ellen,
Schouten Anton N.J.
Publication year - 2014
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12310
Subject(s) - medicine , hypocapnia , cerebral perfusion pressure , perioperative , neurocognitive , anesthesia , anesthetic , cerebral blood flow , perfusion , hemodynamics , blood pressure , hyperventilation , ventilation (architecture) , anesthesiology , intensive care medicine , cardiology , cognition , acidosis , hypercapnia , mechanical engineering , psychiatry , engineering
Summary Neonates have a higher perioperative mortality risk largely due to the degree of prior illness of the infants, the complexity of their surgeries, and infant physiology. It is important to consider contributing anesthetic factors during the perioperative period that may affect cerebral perfusion and neurocognitive outcome, such as alterations in hemodynamics and ventilation. Limitations of blood pressure as a marker for cerebral perfusion are discussed, as well as the effect of hypocapnia on the brain.