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Chloral hydrate sedation for magnetic resonance imaging in newborn infants
Author(s) -
Finnemore Anna,
Toulmin Hilary,
Merchant Naz,
Arichi Tom,
Tusor Nora,
Cox David,
Ederies Ash,
gena Phumza,
Ko Christopher,
Dias Ryan,
Edwards Anthony D.,
Groves Alan M.
Publication year - 2014
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12264
Subject(s) - chloral hydrate , sedation , medicine , magnetic resonance imaging , anesthesia , cohort , adverse effect , chloral , demographics , pediatrics , radiology , chemistry , organic chemistry , demography , sociology
Summary Background The aim of this study was to look for clinically significant adverse effects of chloral hydrate used in a large cohort of infants sedated for magnetic resonance imaging. Method Case notes of infants who underwent magnetic resonance imaging ( MRI ) scanning from 2008 to 2010 were reviewed, with patient demographics, sedation dose, comorbidities, time to discharge, and side effects of sedation noted. Results Four hundred and eleven infants (median [range] postmenstrual age per weight at scan 42 [31 +4 –60] weeks per 3500 g [1060–9900 g]) were sedated with chloral hydrate (median [range] dose 50 [20–80] mg·kg −1 ). In three cases (0.7%), desaturations occurred which prompted termination of the scan. One infant (0.2%) was admitted for additional observation following sedation but had no prolonged effects. In 17 (3.1%) cases, infants had desaturations which were self‐limiting or responded to additional inspired oxygen such that scanning was allowed to continue. Conclusion When adhering to strict protocols, MRI scanning in newborn infants in this cohort was performed using chloral hydrate sedation with a relatively low risk of significant adverse effects.