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Unexpected MH deaths without exposure to inhalation anesthetics in pediatric patients
Author(s) -
Brandom Barbara W.,
Muldoon Sheila M.
Publication year - 2013
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12224
Subject(s) - malignant hyperthermia , ryr1 , medicine , inhalation , contracture , anesthesia , ryanodine receptor , agonist , surgery , receptor
Summary Children, later found to have ryanodine receptor type one variants ( RYR 1 ), died without exposure to inhalation anesthetics. Family members with the same RYR 1 variants had contracture tests consistent with susceptibility to malignant hyperthermia or in vitro testing showed increased sensitivity to RYR 1 agonist.
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