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Samter's triad in childhood: a warning for those prescribing NSAID s
Author(s) -
Ameratunga Rohan,
Randall Nicholas,
Dalziel Stuart,
Anderson Brian J.
Publication year - 2013
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/pan.12216
Subject(s) - medicine , aspirin , asthma , nasal polyps , exacerbation , intensive care medicine , desensitization (medicine) , resuscitation , bronchospasm , respiratory disease , pediatrics , surgery , lung , receptor
Summary Aspirin‐exacerbated respiratory disease ( AERD ) has been recognized in adults with chronic asthma. Samter's triad is a subset of AERD where adult patients develop nasal polyps, asthma, and sensitivity to aspirin. This condition is thought not to occur before the third decade of life. We report a 13‐year‐old boy with nasal polyps who suffered a life‐threatening exacerbation of asthma during a graded aspirin challenge. Resuscitation required positive pressure ventilation and inotropic support. Our observations confirm that classical S amter's triad can occur in children. We suggest that graded aspirin challenges in children are undertaken in a facility with equipment and staff trained for resuscitation. Consideration should be given to this rare complication when prescribing nonsteroidal anti‐inflammatory drugs in the perioperative period. Suspicion of this condition merits referral to an immunologist for desensitization to aspirin.